4-PPBP maleate

SKU: orb1704735

Description

4-PPBP maleate is a potent and selective σ1 receptor agonist and a non-competitive NR1a/2B NMDA receptor antagonist. This dual pharmacological profile underpins its neuroprotective properties, making it a valuable research tool for studying neuropathic pain, ischemia, and neurodegenerative disease models in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 201216-39-9
• MW: 409.52
• Purity: 99.88% (May vary between batches)
• Formula: C₂₅H₃₁NO₄
• SMILES: C(=C\C(O)=O)\C(O)=O.C(CCCC1=CC=CC=C1)N2CCC(CC2)C3=CC=CC=C3
• Target: Sigma receptor,NMDAR,iGluR
• Solubility: Ethanol:< 10.24 mg/mL;DMSO:225 mg/mL (549.42 mM)

Bioactivity

• In Vivo:
  In rats, administration of 4-PPBP maleate (1 μmol/kg; i.v.) leads to a reduction in brain injury following transient focal ischemia.
• In Vitro:
  ERK1/2 phosphorylation is induced by 4-PPBP maleate in primary neurons.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sigma receptor, Sigmareceptor, σ, 4 PPBP maleate, 4PPBP maleate, 4-PPBP Maleate, NR1a/2B NMDA receptor

Compound Identifiers

PubChem CID

11682970