4-Phenoxybenzylamine

SKU: orb1220660

Description

4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .

Images & Validation

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Key Properties

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CAS Number	107622-80-0
MW	199.25
Purity	>98% (HPLC)
Formula	C₁₃H₁₃NO
SMILES	NCc1ccc(Oc2ccccc2)cc1
Target	HCV
Solubility	In Vitro: DMSO : 12.5 mg/mL (62.74 mM)

Bioactivity

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In Vitro	A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

HCV

Protocol Information

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