4-O-Methyl-ascochlorin

SKU: orb3179787

Description

4-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin that selectively induces apoptosis and G1 phase arrest in K562 leukemia cells while downregulating c-Myc expression. It enhances the phosphorylation of AMPK and inhibits the phosphorylation of mTOR and its target proteins [including p70S6 K and 4E-BP-1]. 4-O-Methyl-ascochlorin is useful for leukemia research.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 38561-40-9
• MW: 418.96
• Formula: C₂₄H₃₁ClO₄
• SMILES: C(/C=C(/C=C/[C@]1(C)[C@@H](C)C(=O)CC[C@H]1C)\C)C2=C(OC)C(Cl)=C(C)C(C=O)=C2O
• Target: c-Myc,mTOR,Apoptosis,AMPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

c-Myc,mTOR,Apoptosis,AMPK