4-Methylbenzylidene camphor

SKU: orb1220335

Description

4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations specifically UV B radiation also has estrogenic activities.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 36861-47-9
• MW: 254.37
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂O
• SMILES: Cc1ccc(C=C2C(=O)C3(C)CCC2C3(C)C)cc1
• Target: AChR
• Solubility: DMSO:47 mg/mL (184.77 mM)

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: HTR8/SVneo cells. Concentration: 0, 5, 10, 20, 50, 100, 200, and 400 μM. Incubation time: 48 h. Result: Dose-dependently inhibited cell proliferation of HTR8/SVneo cell. Apoptosis Analysis Cell line: HTR8/SVneo cells. Concentration: 10, 20, 50 μM. Incubation time: 48 h. Result: Early and late apoptotic cells was significantly increased at 20 μM and 50 μM. Cell Cycle Analysis Cell line: HTR8/SVneo cells. Concentration: 5, 10, 20, 50 μM. Incubation time: 48 h. Result: Gradually increased the proportion of cells in the SubG1 phase. Cell Invasion Assay Cell line: HTR8/SVneo cells. Concentration: 50 μM. Incubation time: 48 h. Result: Revealed a significant reduction of 81.5% in invasivenes0. Western blot analysis. Cell line: HTR8/SVneo cells. Concentration: 50 μM. Incubation time: 0, 5, 15, 30, 60, 120 min. Result: The phosphorylation of AKT and its downstream kinase protein, P70S6K, peaked at 5 and 15 min, respectively, subsequently decreased after 30 min, and then reactivated at 120 min RT-PCR Cell line: HTR8/SVneo cells. Concentration: 20, 50 μM. Incubation time: 24 h. Result: Significantly increased the expression of semaphorin 6 A (SEMA6 A), GPR56, integrin subunit beta 4 (ITGB4), EPHB4, neuropilin 1 (NRP1).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-MBC | Enzacamene

Quick Database Links

Gene Symbol

AChR