4-Methoxycinnamyl alcohol

SKU: orb1683501

Description

This natural phenol, isolated from Foeniculum vulgare, exhibits cytotoxic activity against MCF-7, HeLa, and DU145 cancer cell lines. Studies indicate its mechanism involves inducing necrotic cell death rather than apoptosis, making it a useful compound for in vitro research in oncology and cell death pathways.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 53484-50-7
• MW: 164.2
• Purity: 99.80% (May vary between batches)
• Formula: C₁₀H₁₂O₂
• SMILES: COC1=CC=C(\C=C\CO)C=C1
• Target: Histone Methyltransferase,Others

Bioactivity

• Target IC50:
  DU-145 cells:22.10 μg/mL|HeLa cells:7.82 μg/mL|MCF-7 cells:14.24 μg/mL
• In Vitro:
  In the present study, anti-inflammatory effect of hexane, ethyl acetate, and water fractions of rhizomal ethanol extracts of E. pavieana was evaluated for their inhibition on NO production and mechanism in LPS-stimulated macrophages. Inhibitory activities on NO production were performed in LPS-stimulated RAW264.7 macrophage. Cytotoxicity of plant extracts was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, mRNA and protein expressions by reverse transcription-polymerase chain reaction and Western blotting analysis, respectively. Ethyl acetate fraction of E. pavieana (EPE) showed the most potent inhibitory effect on NO production in macrophages. EPE significantly decreased NO production and inhibited inducible nitric oxide synthase (iNOS) protein and mRNA expression in a dose-dependent manner. Furthermore, the level of nuclear factor-kappa B p65 subunit was markedly reduced in activated cells treated with EPE. Four phenolic compounds, 4-Methoxycinnamyl alcohol (1), trans-4-methoxycinnamaldehyde (2), 4-methoxycinnamyl p-coumarate (3), and p-coumaric acid (4), were obtained from bioactivity-guided isolation technique. CONCLUSIONS: The anti-inflammatory property contained in E. pavieana rhizome extract and conferred through inhibition of iNOS expression, and NO formation provides scientific evidence and support for the development of new anti-inflammatory agents based on extracts from this plant.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4Methoxycinnamyl alcohol, 4-Methoxycinnamyl alcohol, 4 Methoxycinnamyl alcohol, NOS, NF-κB, NO, p65

Compound Identifiers

PubChem CID

5314180