4-IPP

SKU: orb1299454

Description

4-Iodo-6-phenylpyrimidine (4-IPP) is a potent, irreversible inhibitor of the cytokine macrophage migration inhibitory factor (MIF). It is widely used in biochemical and cellular research to study MIF's role in inflammatory diseases, cancer, and autoimmune conditions, both in vitro and in animal models.

Research Area

Immunology & Inflammation, Musculoskeletal & Connective Tissue Research

Key Properties

• CAS Number: 41270-96-6
• MW: 282.08
• Purity: 99.63% (May vary between batches)
• Formula: C₁₀H₇IN₂
• SMILES: Ic1cc(ncn1)-c1ccccc1
• Target: Others,MIF
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.09 mM);DMSO:122.5 mg/mL (434.27 mM)

Bioactivity

• In Vivo:
  In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction. Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation.
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• In Vitro:
  4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade.
• Cell Research:
  Cell Line:BMMs. Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM. Incubation Time:24 hours, 72 hours
• Animal Research:
  Animal Model:8-weeks-old C57BL/6J male mice. Dosage:1 mg/kg, 5 mg/kg. Administration:Intraperitoneal injection; every 2 days; for 8 weeks

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4 IPP, 4-Iodo-6-phenylpyrimidine, 4IPP, 4-IPP, inhibit, osteoclastogenesis, osteoblast, MIF, Inhibitor, RANKL

Compound Identifiers

PubChem CID

817368