4-hydroxyphenyl acetate

SKU: orb1298698

Description

This small molecule research compound, 4-Acetoxyphenol, acts as an NRF2 stabilizer to protect retinal pigment epithelial (RPE) cells from necrosis caused by oxidative stress. It is utilized in vitro and in vivo for investigating oxidative injury pathways and potential therapeutic strategies for retinal diseases like AMD.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 3233-32-7
• MW: 152.147
• Purity: 99.82% (May vary between batches)
• Formula: C₈H₈O₃
• SMILES: CC(=O)OC1=CC=C(O)C=C1
• Target: Endogenous Metabolite,Nrf2,Reductase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (13.14 mM);DMSO:30 mg/mL (197.17 mM)

Bioactivity

• In Vitro:
  4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis. Mechanistically, 4-AC blocked the increase of cellular ROS induced by oxidative stress, and upregulated NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor. The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. The tBHQ, an NRF2 stabilizer, consistently mimicked the protective effect of 4-AC against tBHP-induced RPE death.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NRF2, 4hydroxyphenyl acetate, 4-hydroxyphenyl Acetate, 4 hydroxyphenyl acetate

Compound Identifiers

PubChem CID

96009