4-Hydroxyderricin

SKU: orb1710558

Description

4-Hydroxyderricin

Research Area

Cell Biology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 55912-03-3
• MW: 338.4
• Purity: 99.98%
• Formula: C₂₁H₂₂O₄
• SMILES: COc1ccc(C(=O)\C=C\c2ccc(O)cc2)c(O)c1CC=C(C)C
• Target: Dehydrogenase,Monoamine Oxidase,Apoptosis,Hydroxylase,MAO
• Solubility: DMSO:90 mg/mL (265.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.75 mM)

Bioactivity

• Target IC50:
  MAO-B:3.43 μM
• In Vivo:
  4-Hydroxyderricin (50 mg/kg x 2/day; oral) inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation. 4-Hydroxyderricin (10 to 100 microM) inhibited Matrigel-induced formation of capillary-like tubes by HUVECs. The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin.
• In Vitro:
  4-Hydroxyderricin (100 microM) inhibited DNA synthesis in LLC cells, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs. 4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice.

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4 Hydroxyderricin, 4Hydroxyderricin, 4-Hydroxyderricin, MAO-B, DBH

Compound Identifiers

PubChem CID

6438503