4-Diethylaminobenzaldehyde

SKU: orb1310048

Description

4-Diethylaminobenzaldehyde is a potent and reversible inhibitor of aldehyde dehydrogenase 1 (ALDH1) with a Ki of 4 nM. It also exhibits anti-androgenic activity (IC50: 1.71 µM), making it a useful research tool for studying ALDH function and androgen signaling pathways in both cellular and biochemical assays.

Research Area

Metabolism Research

Key Properties

• CAS Number: 120-21-8
• MW: 177.24
• Purity: 99.60% (May vary between batches)
• Formula: C₁₁H₁₅NO
• SMILES: CCN(CC)C1=CC=C(C=O)C=C1
• Target: Dehydrogenase
• Solubility: DMSO:10 mg/mL (56.42 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (5.64 mM)

Bioactivity

• In Vitro:
  4-Diethylaminobenzaldehyde (DEAB) is a reversible competitive inhibitor of ALDH1, with a Ki of 4 nM (competitive with the aldehyde substrate), and it irreversibly inactivates ALDH7A1 by forming a stable, covalent acyl-enzyme species.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

competitive, 4 Diethylaminobenzaldehyde, 4Diethylaminobenzaldehyde, 4-Diethylaminobenzaldehyde, Aldehyde Dehydrogenase (ALDH), ALDH, ALDH1, anti-androgenic, glioblastoma, Inhibitor, inhibit, irreversible

Compound Identifiers

PubChem CID

67114