4'-bromo-Resveratrol

SKU: orb1306240

Description

4'-Bromo-Resveratrol is a cell-permeable, potent inhibitor of the NAD+-dependent deacetylases SIRT1 and SIRT3. This small molecule is a valuable research tool for investigating sirtuin biology in cellular and biochemical assays, with applications in metabolic, aging, and cancer-related research fields.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1224713-90-9
• MW: 291.14
• Purity: 99.40%
• Formula: C₁₄H₁₁BrO₂
• SMILES: Oc1cc(O)cc(\C=C\c2ccc(Br)cc2)c1
• Target: Apoptosis,Sirtuin
• Solubility: DMSO:30 mg/mL (103.04 mM)

Bioactivity

• In Vitro:
  4'-BR treatment of melanoma cells resulted in (a) decrease in proliferation and clonogenic survival; (b) induction of apoptosis accompanied by a decrease in procaspase-3, procaspase-8, and increase in the cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP); (c) marked downregulation of proliferating cell nuclear antigen (PCNA); and (d) inhibition of melanoma cell migration. Further, 4'-BR caused a G0/G1 phase arrest of melanoma cells that was accompanied by an increase in WAF-1/P21 and decrease in Cyclin D1/Cyclin-dependent kinase 6 protein levels. 4'-BR causes a decrease in lactate production, glucose uptake, and NAD+ /NADH ratio. These responses were accompanied by downregulation in lactate dehydrogenase A and glucose transporter 1 in melanoma cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell cycle, antiproliferative, Apoptosis, 4' bromo Resveratrol, 4'bromoResveratrol, 4'-bromo-Resveratrol, 4′‐BR, mitochondrial metabolic reprogramming, inhibit, Inhibitor, melanoma cell growth, SIRT1, Sirtuin-1, Sirtuin-3, Sirtuin, SIRT3

Compound Identifiers

PubChem CID

18475115