(3S,4R)-ME-344

SKU: orb3144667

Description

(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344. As a mitochondrial heme oxygenase-1 (HO-1) inhibitor, ME-344 specifically binds to HO-1 and induces its translocation from the rough endoplasmic reticulum to the mitochondria. ME-344 inhibits mitochondrial ATP production, induces the generation of reactive oxygen species (ROS), and disrupts cellular redox homeostasis and mitochondrial function. It is primarily found in drug-sensitive tumor cells and exhibits significant antitumor activity, making it suitable for research on tumors such as breast cancer.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1374524-84-1
• MW: 348.39
• Formula: C₂₂H₂₀O₄
• SMILES: CC1=C2C([C@H]([C@H](CO2)C3=CC=C(O)C=C3)C4=CC=C(O)C=C4)=CC=C1O
• Target: Reactive Oxygen Species,Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Reactive Oxygen Species,Mitochondrial Metabolism