(3S)-GSK-F1

SKU: orb1685569

Description

(3S)-GSK-F1 is a potent and selective small-molecule inhibitor of PI4KIIIα (pIC50=8.3). This tool compound is used in vitro to study phosphatidylinositol signaling and has been employed in vivo to investigate the kinase's role in viral replication and metabolic disorders.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1384097-27-1
• MW: 603.52
• Purity: 99.35% (May vary between batches)
• Formula: C₂₇H₁₈F₅N₅O₄S
• SMILES: COC1=NC=C(C2=CC=C3N=C([N@@]([C@@]4=CC=CC=C4C(F)(F)F)C(C3=C2)=O)N)C=C1S(=O)(NC5=CC=C(C=C5F)F)=O
• Target: PI4K,PI3K
• Solubility: DMSO:12 mg/mL (19.88 mM)

Bioactivity

• Target IC50:
  PI3Kδ:5.6 (pIC50)|PI4KIIIβ:6.0 (pIC50)|PI4KIIIα:8.3 (pIC50)|PI3Kα:5.6 (pIC50)|PI3Kβ:5.1 (pIC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK-F1, PI4KIIIα, PI4KA inhibitor-F1

Compound Identifiers

PubChem CID

57406702