3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone

SKU: orb1297561

Description

3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone

Research Area

Metabolism Research

Key Properties

• CAS Number: 1178-24-1
• MW: 432.42
• Purity: 99.93% (May vary between batches)
• Formula: C₂₂H₂₄O₉
• SMILES: COc1ccc(cc1OC)-c1oc2c(OC)c(OC)c(OC)c(OC)c2c(=O)c1OC
• Target: Others,PDE
• Solubility: DMSO:12 mg/mL (27.75 mM);10% DMSO+90% Corn Oil:1 mg/mL (2.31 mM)

Bioactivity

• In Vitro:
  3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF), extracted from C. unshiu peels using ethanol extraction and hexane fractionation, inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed matrix metalloproteinases 1 (MMP-1) expression and induced type I procollagen protein expression in these cells. Additionally, HMF inhibited UVB-induced phosphorylation of MAPK cascade signaling components—ERK, JNK, and c-Jun—thereby reducing MMP-1 expression. Furthermore, HMF modulated the TGF-β/Smad signaling pathway by inducing Smad3 and suppressing Smad7 protein expressions in a dose-dependent manner in UV-induced HDFn cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,5,6,7,8,3',4'-Heptemthoxyflavone, 3,3',4',5,6,7,8-heptamethoxyflavone, 3,​5,​6,​7,​8,​3',​4' ​Heptemthoxyflavone, 3,​5,​6,​7,​8,​3',​4'​Heptemthoxyflavone, 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone, gp120/CD4, IL Receptor, Inhibitor, inhibit, TNF-α

Compound Identifiers

PubChem CID

150893