3′,4′,7-Trihydroxyflavone

SKU: orb1297127

Description

7,3',4'-Trihydroxyflavone is a bioactive flavonoid that suppresses osteoclast formation by targeting NFATc1. It potently inhibits RANKL-induced osteoclast differentiation from bone marrow macrophages (BMMs) in vitro, making it a useful research tool for studying bone resorption and osteoporosis-related pathways.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2150-11-0
• MW: 270.24
• Purity: 99.61% (May vary between batches)
• Formula: C₁₅H₁₀O₅
• SMILES: Oc1ccc2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
• Target: COX,ROS,Antibacterial,Akt,ATPase,p38 MAPK,NO Synthase,Bcl-2 Family,ERK,NF-κB,Apoptosis,Caspase,Dehydrogenase,JNK,Interleukin,STAT
• Solubility: DMSO:55 mg/mL (203.52 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RANKL, broad bean pods, ATPase, 3′,4′,7 Trihydroxyflavone , 3′,4′,7-Trihydroxyflavone, 3′,4′,7Trihydroxyflavone , p38MAPK, p38 MAPK, NF-κB, Nuclear factor of activated Tcells (NFAT), NFkB, NFκB, NF-kB, inhibit, Inhibitor, flavonoid aglycon

Compound Identifiers

PubChem CID

5322065