3,4,5-Trihydroxycinnamic acid decyl ester

SKU: orb1691503

Description

3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor with demonstrated anti-obesity effects through the suppression of lipid absorption. It also exhibits anticancer properties, inducing apoptosis in research models of breast and prostate cancer, making it a compound of interest for metabolic and oncology studies.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1770778-45-4
• MW: 336.42
• Purity: 98.28% (May vary between batches)
• Formula: C₁₉H₂₈O₅
• SMILES: CCCCCCCCCCOC(=O)\C=C\c1cc(O)c(O)c(O)c1
• Target: Apoptosis
• Solubility: DMSO:80 mg/mL (237.8 mM)

Bioactivity

• Target IC50:
  Pancreatic lipase:0.9 μM (EC50)
• In Vivo:
  3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) effectively suppresses the elevation of blood triglyceride (TG) levels in 6-week-old male ddY mice administered corn oil orally, with the compound showing a dose-dependent reduction in plasma TG levels at dosages of 30 mg/kg and 150 mg/kg.
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• In Vitro:
  3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) inhibits pancreatic lipase activity by approximately 92% in vitro. This compound exhibits dose-dependent inhibition of pancreatic lipase between 0.1-40 μM, with an EC50 around 0.9 μM. Additionally, it prevents lipid accumulation during 3T3-L1 cell differentiation, indicating potential in influencing lipid metabolism.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, 3,4,5 Trihydroxycinnamic acid decyl ester, 3,4,5Trihydroxycinnamic acid decyl ester, 3,4,5-Trihydroxycinnamic acid decyl ester, pancreatic lipase

Compound Identifiers

PubChem CID

122183243