3',4'-Dihydroxyflavonol

SKU: orb1707753

Description

3',4'-Dihydroxyflavonol (DiOHF) is a flavonol antioxidant shown to enhance endothelial function. It reduces reactive oxygen species and superoxide in diabetic rat mesenteric arteries, while upregulating eNOS expression and nitric oxide bioavailability, supporting vascular research in diabetes models.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 6068-78-6
• MW: 270.24
• Purity: 99.41% (May vary between batches)
• Formula: C₁₅H₁₀O₅
• SMILES: O=C1C(O)=C(OC=2C=CC=CC12)C=3C=CC(O)=C(O)C3
• Target: ROS,Antioxidant,NO Synthase
• Solubility: DMSO:100 mg/mL (370.04 mM)

Bioactivity

• In Vitro:
  3',4'-Dihydroxyflavonol (DiOHF) exhibits significant vascular protective effects under oxidative stress conditions, maintaining the biological activity of nitric oxide (NO) through multiple mechanisms. This compound can effectively alleviate the vasoconstrictive response of the tertiary branches of the rat mesenteric artery through Ca²⁺ desensitization, thereby reducing vascular permeability. At the same time, DiOHF significantly improves NO activity and endothelial function in pathological conditions such as diabetes by inhibiting Nox2-dependent superoxide production and preventing eNOS uncoupling. These synergistic effects make DiOHF a potential vascular function regulator, especially in pathological conditions with elevated reactive oxygen species levels, showing important therapeutic value.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DiOHF, 3',4'Dihydroxyflavonol, 3',4'-Dihydroxyflavonol, 3',4' Dihydroxyflavonol

Compound Identifiers

PubChem CID

145826