306-O12B-3

SKU: orb1568378

Description

306-O12B-3 is an ionizable lipidoid with cationic properties, commonly used in lipid nanoparticle (LNP) formulations for antisense oligonucleotide (ASO) delivery. When administered intravenously in mice, LNPs incorporating 306-O12B-3 exhibit liver-specific accumulation. Studies show that ASO-loaded LNPs containing 306-O12B-3 effectively silence hepatic PCSK9 expression by targeting the proprotein convertase subtilisin/kexin type 9 gene. Additionally, when combined with the cationic lipidoid NT1-O14B (Item No. 37095), these LNPs can deliver tau-targeting ASOs to the brain, reducing tau protein levels in mice.

Key Properties

• CAS Number: 2982842-90-8
• MW: 974.62
• Purity: >95%
• Formula: C₄₆H₉₁N₃O₆S₆
• SMILES: S(CCCCCCCC)SCCOC(CCN(CCC(=O)OCCSSCCCCCCCC)CCCN(C)CCCNCCC(=O)OCCSSCCCCCCCC)=O

Storage & Handling

• Disclaimer: For research use only

Chemical structure of orb1568378