3β-Ursodeoxycholic acid

SKU: orb1708086

Description

3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is an orally well-tolerated and absorbed bile acid. It serves as a research tool for studying bile acid metabolism, as it is enzymatically isomerized in the intestine and liver to produce ursodeoxycholic acid (UDCA).

Research Area

Metabolism Research

Key Properties

• CAS Number: 78919-26-3
• MW: 392.57
• Purity: 98.00% (May vary between batches)
• Formula: C₂₄H₄₀O₄
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C[C@@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
• Target: Drug Metabolite,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.41 mM);DMSO:135 mg/mL (343.89 mM)

Bioactivity

• In Vivo:
  METHODS: 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) or UDCA (2.5 g/kg, orally, for 3 weeks) were given to rats , respectively , to compare the metabolism of UDCA and 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) in experimental cholestasis and the effects on cholestasis in rats. RESULTS3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) was completely converted to UDCA in the liver; cholestasis and cholestatic bile acids were identical after intraduodenal administration of either compound. Oral administration of UDCA or 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) significantly improved hepatic biochemistry in chronic cholestasis, but not clinical and histologic parameters. Translated with DeepL.com (free version)
• In Vitro:
  METHODS: Hep G2 cells were treated with 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) (100 μM) and ethanol (80 μM) to investigate the effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells. The cytotoxic effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells were investigated, as well as the interactions between them. RESULTS 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) did not show any cytotoxic effects and could be cytoprotective against ethanol-induced cell damage. Translated with DeepL.com (free version)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3b-Ursodeoxycholic acid, 3beta-Ursodeoxycholic acid, 3β-Ursodeoxycholic acid, Isoursodeoxycholic acid

Compound Identifiers

PubChem CID

127601