3-TYP

SKU: orb1222814

Description

3-TYP is an inhibitor of SIRT3.(In Vitro):3-TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2 production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd.(In Vivo):3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.

Key Properties

• CAS Number: 120241-79-4
• MW: 146.15
• Purity: >98% (HPLC)
• Formula: C₇H₆N₄
• SMILES: C1(C2=CN=NN2)=CC=CN=C1
• Target: SIRT1| SIRT2| SIRT3
• Solubility: DMSO : 100 mg/mL. 684.23 mM; Ethanol : 16.67 mg/mL 114.06 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-TYP

Quick Database Links

Gene Symbol

SIRT1| SIRT2| SIRT3