3-Phenyltoxoflavin

SKU: orb1303999

Description

3-Phenyltoxoflavin is a small molecule HSP90 inhibitor with a Kd of 585 nM. It exhibits anti-cancer properties and is used in biochemical research to study HSP90-dependent pathways in both cellular and animal models of oncology.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 32502-63-9
• MW: 269.26
• Purity: 99.88% (May vary between batches)
• Formula: C₁₃H₁₁N₅O₂
• SMILES: Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1
• Target: HSP
• Solubility: DMSO:6 mg/mL (22.28 mM)

Bioactivity

• Target IC50:
  HSP90:585 nM (Kd)
• In Vitro:
  3-Phenyltoxoflavin (0.56 nM-100 μM) dose-dependently competes with biotinylated Hsp90 peptide for binding to TPR2A. In BT474 cells, 3-Phenyltoxoflavin (1 nM-100 μM) dose-dependently inhibits cell proliferation with an IC50 of 690 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZINC267655, ZINC-267655, ZINC 267655, Phenyltoxoflavin, HSP90, 3-Phenyltoxoflavin

Compound Identifiers

PubChem CID

460748