3-​O-​Acetyloleanolic acid

SKU: orb1304670

Description

3-​O-​Acetyloleanolic acid

Research Area

Cell Biology

Key Properties

• CAS Number: 4339-72-4
• MW: 498.74
• Purity: 99.57%
• Formula: C₃₂H₅₀O₄
• SMILES: [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](OC(C)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O
• Target: Apoptosis
• Solubility: DMSO:2.5 mg/mL (5.01 mM)

Bioactivity

• In Vitro:
  Expression of TRAIL-mediated apoptosis signaling-related death receptor DR5 was increased in 3-O-acetyloleanolic acid-treated HCT-116 cells. Activation of caspase-8 and caspase-3, critical mediators of extrinsic apoptosis signaling, was also increased by 3-O-acetyloleanolic acid. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5.
• Cell Research:
  Modulation of phosphatidylserine externalization during apoptosis was measured using annexin V conjugated with the fluorescent dye fluorescein isothiocyanate (FITC). The HCT-116 cells were seeded onto 6-well plates at a density of 3*10^5 cells/well. After treatment with 25 uM 3-O-acetyloleanolic acid for 6 h, the cells were stained with the annexin V-FITC conjugate, and then imaged at a^40 objective magnification using a confocal laser scanning microscope.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-O-Acetyloleanolic acid, 3​O​Acetyloleanolic acid, 3 ​O ​Acetyloleanolic acid, Apoptosis, inhibit, Inhibitor

Compound Identifiers

PubChem CID

151202