3-Methoxysalicylaldehyde

SKU: orb1218777

Description

3-Methoxysalicylaldehyde is a natural product.

Key Properties

• CAS Number: 148-53-8
• MW: 152.15
• Purity: >98% (HPLC)
• Formula: C₈H₈O₃
• SMILES: COc1cccc(C=O)c1O
• Target: Others
• Solubility: In Vitro: DMSO : 100 mg/mL (657.25 mM)

Bioactivity

• In Vivo:
  o-Vanillin (2-Vanillin; 60 mg/kg; p.o. ; daily, for 5 d) inhibits tumor growth in mice bearing A375 human melanoma xenografts. Animal model: Male NSG mice with A375 human melanoma xenografts (12-16 weeks of age). Dosage: 60 mg/kg. Administration: Oral administration; daily, for 5 days. Result: Delayed the growth of A375 human melanoma xenografts in immunodeficient NSG mice.
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• In Vitro:
  o-Vanillin (2-Vanillin; 0-125 μg/mL; 24-72 h) inhibits the mycelial growth of A. flavus in a dose-dependent manner. o-Vanillin (0-100 μg/mL; 48 h; A. flavus) changes the morphology of mycelia and induces irregular shrinkage of the mycelia. o-Vanillin (0-100 μg/mL; A. flavus) decreases the protein content of the cell wall surface and the content of β-1, 3-glucan. o-Vanillin (0-100 μg/mL; A. flavus) destroys cell membrane integrity. o-Vanillin releases cell constituents and decreases extracellular pH value. o-Vanillin (0-100 μg/mL) could effectively inhibit the growth of A. flavus on corn kernels. o-Vanillin (0-250 μM) inhibits doxorubicin-mediated induction of NF B activity by 65% in A375/NF B-Luc cells. o-Vanillin suppresses 4-HC-induced activity by 43%.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others