3′-Me Meayamycin D

SKU: orb2945242

Description

3’-Me Meayamycin D is a potent SF3B1/PHF5A-targeting splice modulator that downregulates MCL-1. It inhibits proliferation in cancer cell lines (e.g., HCT116, A549) with GI50 values of 4.6-7.2 nM and exhibits good in vivo plasma stability (t1/2 ~16 h in mice), supporting its use in oncology and splicing mechanism research.

Key Properties

• MW: 521.686
• Formula: C₂₉H₄₇NO₇
• SMILES: C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(CC(O2)(C)C)CO3)O)C)NC(=O)/C=C(/C)\[C@H](C)OCOC
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676962