3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles

SKU: orb2564461

Description

This small molecule is a dual inhibitor of BMP2 (IC50 = 2.2 µM) and MEK1. It has demonstrated anti-inflammatory and neuroprotective activity in the EAE mouse model, supporting its use in research on neuroinflammation, bone biology, and MAPK/MEK signaling pathways.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 287196-91-2
• MW: 285.25
• Formula: C₁₁H₆F₃N₃OS
• SMILES: N#CC=1C(=O)NSC1NC=2C=CC=CC2C(F)(F)F
• Target: TGF-beta/Smad,MEK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

2726567