3-Ethoxy-5,6-dibromosalicylaldehyde

SKU: orb3175112

Description

3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor with IC50 values of approximately 0.12 μM for hIRE1α-cyto and 6 μM for yeast Ire1. It suppresses XBP-1 splicing and induces apoptosis. This compound upregulates TXNIP mRNA expression levels while downregulating TXN expression. Furthermore, 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer and significantly inhibits the replication of the chikungunya virus.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 20041-64-9
• MW: 323.97
• Formula: C₉H₈Br₂O₃
• SMILES: O=CC=1C(Br)=C(Br)C=C(OCC)C1O
• Target: Arrestin,Apoptosis,IRE1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Arrestin,Apoptosis,IRE1