3-Deoxyglucosone

SKU: orb1706302

Description

3-Deoxyglucosone is a reactive dicarbonyl compound formed via the Maillard and polyol pathways. It readily forms advanced glycation end products (AGEs) with proteins, serves as a biomarker for diabetes research, and modulates biological processes such as GLP-1 secretion and oxidative stress in experimental studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4084-27-9
• MW: 162.14
• Purity: 95.00% (May vary between batches)
• Formula: C₆H₁₀O₅
• SMILES: [C@H](CC(C=O)=O)([C@@H](CO)O)O
• Target: Glucagon Receptor,GPX

Bioactivity

• In Vivo:
  3-Deoxyglucosone (20 mg/kg; intragastric administration; single dose) induces a deterioration in glucose tolerance, as evidenced by an increased Area Under the Curve (AUC). Plasma glucagon levels do not show significant differences. The administration of 3-Deoxyglucosone leads to the development of impaired glucose regulation (IGR) accompanied by evident dysfunction of pancreatic islet cells in both Kunming mice and SD rats. 3-deoxyglucosone (5-50 mg/kg; gastric gavage; once daily; 2 weeks; SD rats) exhibits significant increases in the upper small intestine (1.4-fold), lower small intestine (1.4-fold), ileum (1.4-fold), and colon (two-fold) compared to basal levels in their respective control groups. Additionally, there is a noteworthy decrease in the protein expressions of TAS1R2, TAS1R3, and TRPM5 observed in both the duodenum and colon.
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• In Vitro:
  3-Deoxyglucosone (80 ng/ml-1000 ng/ml; 1 hour; STC-1 cells) induces a 1.23-fold increase in GLP-1 secretion at 300 ng/ml and 1000 ng/ml, while 80 ng/ml shows no effect. At 300 ng/ml, 3DG significantly elevates intracellular Ca2+ levels, as measured by Fluo-3/AM (2.5 μM for 30 mins), but does not affect intracellular cAMP in a cAMP Elisa assay. Additionally, 300 ng/ml 3DG significantly enhances TAS1R2, TAS1R3, and TRPM5 protein expression under both glucose-free and high conditions.
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• Cell Research:
  Cell Line: STC-1 cells. Concentration: 300 ng/ml. Incubation Time: 1 hour
• Animal Research:
  Animal Model: SD rats. Dosage: 5, 20 and 50 mg/kg. Administration: oral administration; once daily; 2 weeks

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-keto-3-Deoxyglucose, 3-Deoxyglucosone, 3-Deoxy-D-glucosone, GPX, GLP Receptor, GlucagonReceptor, Glucagon Receptor

Compound Identifiers

PubChem CID

114839