3-demethylcolchicine

SKU: orb1297034

Description

3-Demethylcolchicine is a bioactive compound isolated from Gloriosa superba. It acts as a tubulin polymerization inhibitor, specifically targeting purified bovine brain tubulin in vitro. This property makes it a valuable tool for studying cytoskeleton dynamics and mitotic disruption in cell biology research.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 7336-33-6
• MW: 385.41
• Purity: 98.24% (May vary between batches)
• Formula: C₂₁H₂₃NO₆
• SMILES: COc1c(O)cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c1OC
• Target: Reactive Oxygen Species,ROS
• Solubility: DMSO:10 mg/mL (25.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.59 mM)

Bioactivity

• In Vitro:
  3-demethylcolchicine showed an appreciable effect in vitro and in vivo, in the lymphocytic leukemia P388 screen in mice, for their toxicity in mice, and for their binding to microtubule protein.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

colchicine, edema, 3-demethylcolchicine, 3demethylcolchicine, 3-Demethylcolchicine, 3 demethylcolchicine, carrageenin, inhibit, Inhibitor, metabolite, radical, Reactive Oxygen Species, ReactiveOxygenSpecies, scavenging

Compound Identifiers

PubChem CID

299664