3-demethylcolchicine

SKU: orb1297034

Description

3-Demethylcolchicine is a bioactive compound isolated from Gloriosa superba. It acts as a tubulin polymerization inhibitor, specifically targeting purified bovine brain tubulin in vitro. This property makes it a valuable tool for studying cytoskeleton dynamics and mitotic disruption in cell biology research.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 7336-33-6
• MW: 385.41
• Purity: 98.87% (May vary between batches)
• Formula: C₂₁H₂₃NO₆
• SMILES: COc1c(O)cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c1OC
• Target: Reactive Oxygen Species
• Solubility: DMSO:10 mg/mL (25.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.59 mM)

Bioactivity

• In Vitro:
  3-demethylcolchicine showed an appreciable effect in vitro and in vivo, in the lymphocytic leukemia P388 screen in mice, for their toxicity in mice, and for their binding to microtubule protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

colchicine, edema, 3-demethylcolchicine, 3demethylcolchicine, 3-Demethylcolchicine, 3 demethylcolchicine, carrageenin, inhibit, Inhibitor, metabolite, radical, Reactive Oxygen Species, ReactiveOxygenSpecies, scavenging

Compound Identifiers

PubChem CID

299664