3-Deazauridine

SKU: orb1303896

Description

3-Deazauridine (NSC-126849) is a uridine analog functioning as a competitive inhibitor of cytidine triphosphate synthetase (CTPS), thereby blocking CTP biosynthesis. This mechanism supports its research use in studying nucleotide metabolism, with applications in antiviral and anticancer investigations across in vitro and in vivo models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 23205-42-7
• MW: 243.21
• Formula: C₁₀H₁₃NO₆
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)C=C(O)C=C2
• Target: Nucleoside Antimetabolite/Analog
• Solubility: DMF:16 mg/mL (65.79 mM);DMSO:45 mg/mL (185.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.22 mM)

Bioactivity

• In Vitro:
  3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Analog, 3Deazauridine, 3-Deazauridine, 3 Deazauridine, NSC126849, NSC-126849, Nucleoside Antimetabolite, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, NSC 126849

Compound Identifiers

PubChem CID

54684286