3-Bromocytisine

SKU: orb1710577

Description

(-)-3-Bromocytisine is a potent and selective nicotinic acetylcholine receptor (nAChR) agonist, exhibiting high affinity for human α4β4 and α4β2 subtypes with IC50 values in the sub-nanomolar range. This small molecule is a valuable research tool for investigating nAChR function and pharmacology in neurobiological studies, including in vitro binding and functional assays.

Research Area

Neuroscience

Key Properties

• CAS Number: 207390-14-5
• MW: 269.14
• Purity: 99.97%
• Formula: C₁₁H₁₃BrN₂O
• SMILES: O=C1N2C([C@@]3(C[C@](C2)(CNC3)[H])[H])=CC=C1Br
• Target: AChR
• Solubility: DMSO:50 mg/mL (185.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.43 mM)

Bioactivity

• Target IC50:
  α7 (human):31.6 nM |α4β2 (human):0.30 nM |α4β4 (human):0.28 nM
• In Vitro:
  3-Bromocytisine shows different effects on high and low ACh sensitivity α4β2 nAChRs with EC50s are 8 and 50 nM, respectively .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

nAChR, (-)-3-Bromocytisine, (-)-9-Bromocytisine, 3-Br-cytisine, 3-Bromocytisine, 9-Bromocytisine

Compound Identifiers

PubChem CID

15519735