3-Bromo-7-nitroindazole

SKU: orb1310058

Description

3-Bromo-7-nitroindazole

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 74209-34-0
• MW: 242.03
• Purity: 98.20% (May vary between batches)
• Formula: C₇H₄BrN₃O₂
• SMILES: O=[N+](C1=CC=CC2=C1NN=C2Br)[O-]
• Target: NO Synthase,NOS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.53 mM);DMSO:100 mg/mL (413.17 mM)

Bioactivity

• In Vivo:
  Male rats received either 3-Bromo-7-nitroindazole (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Bromo-7-nitroindazole impaired the acquisition of the Morris water maze (MWM) paradigm task. 3-Bromo-7-nitroindazole also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Bromo-7-nitroindazole treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Bromo-7-nitroindazole was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Bromo-7-nitroindazole treated rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3 Bromo 7 nitroindazole, 3Bromo7nitroindazole, 3-Bromo-7-nitroindazole, Inhibitor, Nitric oxide synthases, NO Synthase, nNOS, inhibit, NOS

Compound Identifiers

PubChem CID

1649