3'-Azido-3'-deoxy-5-methylcytidine

SKU: orb1310050

Description

This compound, 3'-azido-3'-deoxy-5-methylcytidine, is a potent inhibitor of HIV-1 reverse transcriptase (EC50 = 0.06 µM) and also exhibits activity against xenotropic murine leukemia-related virus (XMRV). It serves as a valuable research tool for investigating retroviral replication mechanisms in both in vitro enzymatic and cell-based antiviral assays.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 1282040-14-5
• MW: 282.26
• Purity: 99.86% (May vary between batches)
• Formula: C₁₀H₁₄N₆O₄
• SMILES: Cc1cn([C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])[C@H]2O)c(=O)nc1N
• Target: Reverse Transcriptase,Antiviral,HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.69 mM);DMSO:80 mg/mL (283.43 mM)

Bioactivity

• Target IC50:
  XMRV:43.5 μM (CC50, in MCF-7 cells)|HIV-1:0.06 μM (EC50, in PBM cells)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3'-Azido-3'-deoxy-5-methylcytidine, 3'Azido3'deoxy5methylcytidine, 3' Azido 3' deoxy 5 methylcytidine, Antiviral, Inhibitor, inhibit, Human immunodeficiency virus, HIVProtease, HIV Protease, HIV-1 reverse transcriptase, HIV, Reverse Transcriptase

Compound Identifiers

PubChem CID

101644650