3′-Azido-2′,3′-dideoxy-CTP

SKU: orb3136353

Description

3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analogue containing a 3-azido group. It functions as a chain terminator when incorporated into nascent DNA strands by HIV reverse transcriptase, effectively inhibiting DNA synthesis due to the absence of a 3'-hydroxyl group, thereby blocking viral replication. The IC50 for WTHIV is 15.6 μM, and for AZTRHIV, it is 160.8 μM. This compound exhibits antiviral activity.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 92562-77-1
• MW: 492.17
• Formula: C₉H₁₅N₆O₁₂P₃
• SMILES: O=C1N([C@@H]2O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](N=[N+]=[N-])C2)C=CC(N)=N1
• Target: DNA/RNA Synthesis,HIV Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis,HIV Protease