3-Aminobenzamide

SKU: orb1300864

Description

3-Aminobenzamide

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 3544-24-9
• MW: 136.15
• Purity: 99.84%
• Formula: C₇H₈N₂O
• SMILES: NC(=O)C1=CC(N)=CC=C1
• Target: PARP
• Solubility: DMSO:55 mg/mL (403.97 mM);Ethanol:26 mg/mL (190.97 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (36.72 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  PARP < 0 nM
• In Vivo:
  In a db/db (Leprdb/db) mouse model, INO-1001 ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. Treatment with INO-1001 (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice.
• In Vitro:
  INO-1001 (>1 μM) leads to more than 95% Inhibition of PARP activity without significant cellular toxicity. In addition, INO-1001 significantly sensitizes CHO cells by blocking most o the DNA repair occurring between radiation fractions. Inhibition of PARP activity by INO-1001 significantly improves endothelial function by enhancin the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM Water2.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

3-AB, 3-ABA, 3Aminobenzamide, 3-Aminobenzamide, 3 Aminobenzamide, Inhibitor, INO 1001, INO1001, INO-1001, inhibit, PARP, PARP-IN-1, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

1645