3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one

SKU: orb1298680

Description

DMU2105 is a potent and selective CYP1B1 inhibitor, exhibiting an IC50 of 10 nM for CYP1B1 versus 742 nM for CYP1A1. This small molecule is a valuable chemical probe for studying CYP1B1's role in steroid metabolism, chemical carcinogenesis, and in cancer cell resistance mechanisms in vitro.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1031063-36-1
• MW: 259.3
• Purity: 99.84% (May vary between batches)
• Formula: C₁₈H₁₃NO
• SMILES: C(=CC(=O)C=1C=CC=NC1)C2=CC3=C(C=C2)C=CC=C3
• Target: Cytochromes P450
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (7.71 mM);DMSO:25 mg/mL (96.41 mM)

Bioactivity

• Target IC50:
  CYP1A1:742 nM|CYP1B1:10 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one, DMU2105, DMU-2105, CYP1B1

Compound Identifiers

PubChem CID

72079643