(2Z,3Z)-U0126

SKU: orb1739654

Description

U0126 is a potent and selective noncompetitive inhibitor of MEK1 and MEK2 (IC50: 72 nM and 58 nM, respectively), blocking the MAPK/ERK pathway. It suppresses AP-1 activity and has been used in vitro to inhibit the anchorage-independent growth of ras-transformed cells and in vivo to study cancer and neurological disease models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 218601-62-8
• MW: 380.49
• Formula: C₁₈H₁₆N₆S₂
• SMILES: C(/C(=C(/SC1=C(N)C=CC=C1)\N)/C#N)(=C(\SC2=C(N)C=CC=C2)/N)\C#N
• Target: Others,MEK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

3006531