(2S)-2'-Methoxykurarinone

SKU: orb1297511

Description

(2S)-2'-Methoxykurarinone, a bioactive flavonoid from Sophora flavescens, exhibits anti-inflammatory, antidiabetic, and antineoplastic properties. Research indicates it inhibits osteoclastogenesis by downregulating RANKL signaling and shows cytotoxic activity against HL-60 leukemia cells in vitro.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 270249-38-2
• MW: 452.54
• Purity: 99.44% (May vary between batches)
• Formula: C₂₇H₃₂O₆
• SMILES: COc1cc(O)ccc1[C@@H]1CC(=O)c2c(OC)cc(O)c(C[C@@H](CC=C(C)C)C(C)=C)c2O1
• Target: Akt,Antifection,RANKL/RANK
• Solubility: DMSO:24 mg/mL (53.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.42 mM)

Bioactivity

• In Vitro:
  2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2'-O-Methylkurarinone, 2'-Methoxykurarinone, (2S) 2' Methoxykurarinone, (2S)2'Methoxykurarinone, Akt, Antifection, Inhibitor, inhibit

Compound Identifiers

PubChem CID

11982641