2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

SKU: orb1305992

Description

GDC046 is a potent and selective kinase inhibitor lead compound with favorable drug-like properties. It serves as a valuable research tool for investigating kinase signaling pathways in both cellular and animal models of disease.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1258292-64-6
• MW: 350.2
• Purity: 99.65% (May vary between batches)
• Formula: C₁₆H₁₃Cl₂N₃O₂
• SMILES: Clc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1
• Target: JAK
• Solubility: DMSO:3.51 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.86 mM)

Bioactivity

• Target IC50:
  JAK3:0.4 nM (Ki)|TYK2:4.8 nM (Ki)|JAK1:0.7 nM (Ki)|JAK2:0.7 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diseases, 2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide, 2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide, bowel, Inhibitor, GDC 046, GDC046, GDC-046, IBD, inhibit, IL-23, IL-12, JAK, JAK1, JAK2, Janus kinase, JAK3, inflammatory, TYK2

Compound Identifiers

PubChem CID

49839561