26-Deoxyactein

SKU: orb1297509

Description

23-epi-26-Deoxyactein is a bioactive small molecule with demonstrated anti-inflammatory and anti-cancer properties. It suppresses nitric oxide production by downregulating iNOS expression and inhibits proliferation of MCF-7 breast cancer cells by inducing G1 phase cell cycle arrest, making it a candidate for inflammation and oncology research.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 264624-38-6
• MW: 660.83
• Purity: 99.90% (May vary between batches)
• Formula: C₃₇H₅₆O₁₀
• SMILES: [H][C@@]12O[C@]1(C)CO[C@]21C[C@@H](C)[C@@]2([H])[C@]([H])(C[C@@]3(C)[C@]4([H])CC[C@]5([H])[C@]6(C[C@@]46C[C@@H](OC(C)=O)[C@]23C)CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C5(C)C)O1
• Target: ERK,Aryl Hydrocarbon Receptor,CDK,NOS,NO Synthase
• Solubility: DMSO:70 mg/mL (105.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.03 mM)

Bioactivity

• In Vitro:
  Black cohosh rhizomes were extracted with methanol/water and fractionated by solvent-solvent partitioning to yield three fractions: hexane, ethyl acetate and water. The ethyl acetate fraction displayed the highest potency in two cell-based assays, growth inhibition and cell cycle analysis. This fraction inhibited growth of both the ER+ MCF7 and ER-MDA-MB-453 human breast cancer cell lines with IC50 values of about 20 and 10 micro g/ml, respectively. It also induced cell cycle arrest at G1 when tested at 30 micro g/ml and at G2/M at 60 micro g/ml in MCF7 cells. This suggests that the extract contains a mixture of components with the more active (or more abundant) causing G1 arrest and the less active causing G2/M arrest. We then examined specific components in this extract. The triterpene glycoside fraction obtained by polyamide column chromatography, and the specific triterpene glycosides actein, 23-epi-26-Deoxyactein and cimiracemoside A, inhibited growth of the MCF7 human breast cancer cells and induced cell cycle arrest at G1

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK, 26 Deoxyactein, 27-Deoxyactein, 26Deoxyactein, 26-Deoxyactein, NOS, NOSynthase, NO Synthase

Compound Identifiers

PubChem CID

10974362