2,5-dimethyl Celecoxib

SKU: orb1304059

Description

2,5-dimethyl Celecoxib is a celecoxib-based small molecule that selectively inhibits microsomal prostaglandin E synthase-1 (mPGES-1), a pivotal enzyme in inflammatory prostaglandin E2 biosynthesis. This inhibitor is utilized in research to investigate inflammation, pain, and cancer pathways in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 457639-26-8
• MW: 395.4
• Purity: 99.85% (May vary between batches)
• Formula: C₁₈H₁₆F₃N₃O₂S
• SMILES: CC1=CC(C2=CC(=NN2C2=CC=C(C=C2)S(N)(=O)=O)C(F)(F)F)=C(C)C=C1
• Target: Prostaglandin Receptor,Survivin,Apoptosis,Wnt/beta-catenin
• Solubility: Ethanol:3 mg/mL (7.59 mM);DMSO:60 mg/mL (151.75 mM);DMF:5 mg/mL (12.65 mM);DMSO:PBS (pH 7.2) (1:3):0.25 mg/mL (0.63 mM)

Bioactivity

• In Vivo:
  2,5-dimethyl Celecoxib prevented cardiac remodeling and markedly reduced urinary albumin excretion without altering blood pressure in mice. 2,5-dimethyl Celecoxib prevented podocyte injury, glomerulosclerosis, and interstitial fibrosis in the kidney of mice loaded with angiotensin II and high-salt load. 2,5-dimethyl Celecoxib reduced the phosphorylation level of Akt and activated glycogen synthase kinase-3, which led to the suppression of the Wnt/β-catenin signal in the heart and kidney. 2,5-dimethyl Celecoxib also reduced the expression level of snail, a key transcription factor for the epithelial–mesenchymal transition and of which gene is a target of the Wnt/β-catenin signal.
• In Vitro:
  2,5-dimethyl Celecoxib(1–100 μM) decreased the viability of GBM cell lines in a dose-dependent manner. 2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in A-172, T98G and U-138 MG cell lines. Apoptosis was induced, and cell cycle distribution was altered after the treatment with 2,5-dimethyl Celecoxib in T98G cell line.2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in patient-derived primary GBM cell lines P1 and P6.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, Apoptosis, 2,5 dimethyl Celecoxib, 2,5dimethyl Celecoxib, 2,5-dimethyl Celecoxib, Wnt, Wnt/betacatenin, Wnt/b-catenin, Wnt/β-catenin, PGE2, Prostaglandin Receptor, ProstaglandinReceptor, βcatenin

Compound Identifiers

PubChem CID

11545682