2,3-Butanedione 2-Monoxime

SKU: orb1224609

Description

Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.

Key Properties

• CAS Number: 57-71-6
• MW: 101.11
• Purity: >98% (HPLC)
• Formula: C₄H₇NO₂
• SMILES: C/C(=N\O)/C(=O)C
• Target: Akt
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Biacetyl monoxime (0-200 mg/kg; i. v. ; once) shows hypotensive effect. Biacetyl monoxime (0-205 mg/kg; i.p.; once) shows anticonvulsant effect against Picrotoxin (HY-101391)-induced convulsions. Animal model: Male SHR and age-matched WKY rat. Dosage: 5, 30, I00 and 200 mg/kg. Administration: Intravenous administration, 1 mL/kg, once. Result: Decreased arterial blood pressure for both strains, the SHR was significantly more responsive. Animal model: Male mice (20 to 25 g). Dosage: 51, 103 and 205 mg/kg in combination with intraperitoneal injection of 3.0 mg/kg Picrotoxin (HY-101391). Administration: Intraperitoneal injection, once. Result: Showed dose-dependent anticonvulsant effect against Picrotoxin-induced convulsions.
• In Vitro:
  Biacetyl monoxime (Diacetyl monoxime) (50 mM, 6 and 48 h) decreases cellulase secretion in C. cinerea. Biacetyl monoxime (50 mM, 2 and 4 h) disrupts the localization of the Golgi apparatus, but not that of the endoplasmic reticulum. Biacetyl monoxime (0-30 mM) induces SR Ca2+ release (no efflux inhibitors) in a concentration-dependent manner, with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase, which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction. Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms, myosin-V, or myosin-VI. Biacetyl monoxime (0-50 mM) suppresses L-type Ca2+ current of single cardiac myocytes isolated from SHR and WKY rats. Biacetyl monoxime significantly reduces the duration of both spontaneous and electrically stimulated action potentials of cultured neonatal rat cardiomyocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BDM | Diacetyl Monoxime | NSC 660 | NSC 116103

Quick Database Links

Gene Symbol

Akt