2,2,2-Trichloroethanol

SKU: orb1303771

Description

2,2,2-Trichloroethanol is a chemical activator of the mechanosensitive two-pore domain potassium channels TREK-1 and TRAAK. This compound is a valuable research tool for investigating the roles of these K2P channels in pain sensation, neuroprotection, and depression in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 115-20-8
• MW: 149.4
• Purity: 99.74% (May vary between batches)
• Formula: C₂H₃Cl₃O
• SMILES: OCC(Cl)(Cl)Cl
• Target: Potassium Channel,Endogenous Metabolite
• Solubility: DMSO:55 mg/mL (368.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (13.39 mM)

Bioactivity

• In Vitro:
  2,2,2-trichloroethanol dilated the middle cerebral artery and activated the potassium channel in cerebrovascular smooth muscle.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, hydrate, Human Endogenous Metabolite, hypnotic, Inhibitor, KcsA, KCNK2, KCNK4, inhibit, K(+), nonclassical, non-classical, 2,2,2Trichloroethanol, 2,2,2-Trichloroethanol, 2,2,2 Trichloroethanol, channel, channels, chloral, TREK-1, TRAAK, Potassium Channel, potassium, PotassiumChannel

Compound Identifiers

PubChem CID

8259