22-(4′-py)-JA

SKU: orb2277857

Description

22-(4′-py)-JA is a semisynthetic junamycin A derivative that demonstrates potent antimetastatic activity, particularly against NSCLC. It functions by inhibiting the AKT/mTOR/p70S6K pathway, thereby suppressing tumor cell invasion, angiogenesis, and the expression of key proteins like MMP-2, MMP-9, HIF-1α, and VEGF in models such as HUVECs.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1178895-15-2
• MW: 598.6
• Formula: C₃₂H₃₀N₄O₈
• SMILES: C(OC(=O)C=1C=CN=CC1)[C@@H]2N3[C@]([C@]4(C5=C(C[C@@]([C@@H]3C#N)(N4C)[H])C(=O)C(C)=C(OC)C5=O)[H])(CC6=C2C(=O)C(OC)=C(C)C6=O)[H]
• Target: Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

45268237