21-deacetyldeflazacort

SKU: orb1304830

Description

21-Deacetyldeflazacort is the primary active metabolite of the corticosteroid deflazacort. It is used in pharmacological research to study glucocorticoid receptor-mediated anti-inflammatory and immunosuppressive effects in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 13649-57-5
• MW: 399.48
• Purity: 99.96% (May vary between batches)
• Formula: C₂₃H₂₉NO₅
• SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)=N2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]
• Target: Drug Metabolite,Others
• Solubility: DMSO:65 mg/mL (162.71 mM)

Bioactivity

• In Vivo:
  21-deacetyldeflazacort inhibited 48-h homologous passive cutaneous anaphylaxis in rats, but had no significant effects on active systemic anaphylaxis in mice, on the Schultz-Dale reaction in the isolated guinea-pig trachea or on compound 48/80-induced histamine release in rat peritoneal mast cells. 21-deacetyldeflazacort inhibited reversed cutaneous anaphylaxis in rats and the Arthus reaction in mice.
• In Vitro:
  21-deacetyldeflazacort displaces [3H]dexamethasone from its cytosol receptor sites in rat kidney, thymus and liver in vitro.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

21deacetyldeflazacort, 21-deacetyldeflazacort, 21 deacetyldeflazacort

Compound Identifiers

PubChem CID

3081431