20-HETE

SKU: orb1989621

Description

This small molecule, 20-HETE, is a bioactive lipid that stimulates cancer cell proliferation and migration. It serves as a research tool for studying prostate cancer and cardiac hypertrophy models, as it activates the PKC pathway to upregulate FBXO10 expression in both in vitro and in vivo experimental systems.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 79551-86-3
• MW: 320.47
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₃₂O₃
• SMILES: C(=C\C/C=C\C/C=C\CCCCCO)\C/C=C\CCCC(O)=O
• Target: PKC
• Solubility: DMSO:2 mg/mL (6.24 mM);Ethanol:5 mg/mL (15.6 mM)

Bioactivity

• In Vivo:
  20-HETE contributes to DHT-induced vascular remodeling, independent of blood pressure elevation.
• In Vitro:
  17-ODYA (1 μM) increased the activity of large-conductance Ca(2+)-activated K+ channels, and this effect was reversed by 20-HETE (10 nM). 20-HETE (1-1000 nM) reduced the diameter of isolated perfused small renal arteries in rats by approximately 15%, and TEA (1 mM) blocked the vasoconstrictor response to 20-HETE (100 nM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

20 HETE, 20-hydroxy Arachidonic Acid, 20HETE, 20-HETE, Human Endogenous Metabolite, PKC

Compound Identifiers

PubChem CID

5283157