20-HC-Me-Pyrrolidine

SKU: orb1687663

Description

20-HC-Me-Pyrrolidine is a potent small molecule inhibitor of Aster-A, -B, and -C proteins (IC50 0.06-0.71 µM). It effectively blocks cholesterol binding and transfer, specifically inhibiting LDL-cholesterol movement to the ER. This compound is a valuable research tool for studying intracellular cholesterol trafficking and Aster protein function in both cellular and animal models of lipid metabolism.

Research Area

Metabolism Research

Key Properties

• MW: 429.68
• Purity: 99.99% (May vary between batches)
• Formula: C₂₈H₄₇NO₂
• SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(C)(C)O)CC=C4[C@@]3(CC[C@@H](C4)OCCN5CCCC5)C
• Target: CETP,LDL,LDLR,Others
• Solubility: DMSO:13.15 mg/mL (30.6 mM);50% PEG300+50% Saline:2 mg/mL (4.65 mM)

Bioactivity

• Target IC50:
  Aster-C:1.41 μM|Aster-A:0.87 μM|Aster-B:0.21 μM
• In Vitro:
  20-HC-Me-Pyrrolidine is a potent inhibitor of Aster proteins, with IC₅₀ values of 0.87 μM for Aster-A, 0.21 μM for Aster-B, and 1.41 μM for Aster-C .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163196428