20-DEOXYINGENOL

SKU: orb1220707

Description

20-DEOXYINGENOL is a natual product.

Key Properties

• CAS Number: 54706-99-9
• MW: 332.43
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₈O₄
• SMILES: [H][C@@]12C[C@@H](C)[C@]34C=C(C)[C@H](O)[C@@]3(O)[C@H](O)C(C)=C[C@]([H])(C4=O)[C@]1([H])C2(C)C
• Target: Others
• Solubility: DMSO:50 mg/mL (150.41 mM)

Bioactivity

• In Vivo:
  20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice. Animal model: 10-week-old C57BL/6 male wild-type (WT) mice with destabilization of the medial meniscus (DMM). Dosage: 20 mg/kg. Administration: i.p. one time per day, for eight consecutive weeks. Result: Had a slightly wider joint space and reduced bone density and calcification compared with the DMM group. Inhibited the decrease in the thickness of hyaline cartilage (HC), and alleviated the disorder and hypertrophy of chondrocytes in the joint tissues of mice after DMM surgery. Had less erosion on the surface of the articular cartilage and more proteoglycan content. Had more positive staining points of LAMP1 and LC3 II, and less cleaved-caspase3 and P16INK4a. Increased the nuclear level of TFEB.
• In Vitro:
  20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100 μM)-induced cell death.20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes.20-Deoxyingenol (2.5-40 mM; 24 h) has no cytotoxic effect on chondrocytes at the concentration less than 10 mM.20-Deoxyingenol (10 mM; 24 h) restores autophagy flux in TBHP treated chondrocytes.20-Deoxyingenol (4-10 mM; 24 h) promotes the nuclear level of TFEB in TBHP treated chondrocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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