2-PyriMidinaMine, 4-[3-fluoro-5-(4-Morpholinyl)phenyl

SKU: orb3027371

Description

2-Pyridinamine, 4-[3-fluoro-5-(4-morpholinyl)phenyl] (Compound 9l) is an ATP-competitive JNK (c-Jun N-terminal kinase) inhibitor with IC₅₀ values of 0.099 μM and 0.148 μM for JNK1 and JNK3 respectively, exhibiting the advantage of blood-brain barrier penetration. 2-Pyridinamine, 4-[3-fluoro-5-(4-morpholinyl)phenyl] inhibits c-Jun phosphorylation and reactive oxygen species (ROS) generation, making it suitable for neurodegenerative disease research.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1128096-64-9
• MW: 502.54
• Purity: 99.94%
• Formula: C₂₆H₂₇FN₈O₂
• SMILES: FC1=CC(=CC(=C1)N2CCOCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5N=C(N=C5)N6CCOCC6
• Target: ROS,JNK

Bioactivity

• Target IC50:
  JNK1:0.099 μM|JNK3:0.148 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2PyriMidinaMine,4[3fluoro5(4Morpholinyl)phenyl

Quick Database Links

Gene Symbol

ROS,JNK