2-Propylpent-4-ynoic acid

SKU: orb3211283

Description

2-Propylpent-4-ynoic acid (4-yn-VPA) is identified as an HDAC inhibitor, with an IC50 value of 0.5 mM against human HDAC. It induces P-glycoprotein function and exhibits teratogenic effects, fetal growth inhibition, and neurotoxicity. The compound demonstrates significant stereospecific teratogenic effects, with the S-enantiomer being more teratogenic than the R-enantiomer and other analogs, although its neurotoxicity is not associated with stereochemistry. This compound has been utilized in studies related to the pathogenesis of colon cancer and neural tube defects, such as exencephaly.

Key Properties

• CAS Number: 24102-11-2
• MW: 140.18
• Formula: C₈H₁₂O₂
• SMILES: O=C(O)C(CC#C)CCC
• Target: P-gp,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp,HDAC