2-Methoxyestradiol

SKU: orb1225199

Description

2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro; suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice; also downregulates hypoxia-inducible factor-1 (HIF) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.

Key Properties

• CAS Number: 362-07-2
• MW: 302.4079
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₆O₃
• SMILES: OC1=C(OC)C=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1
• Target: HIF/HIF Prolyl-hydroxylase
• Solubility: DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2ME2 | NSC-659853

Quick Database Links

Gene Symbol

HIF/HIF Prolyl-hydroxylase