2-Hydroxychalcone

SKU: orb1299329

Description

This small molecule, a methoxylated derivative of 2-hydroxychalcone, acts as a potential antiparasitic agent and inhibits the invasion of triple-negative breast cancer cells in vitro. Its biological activity makes it a candidate for research in oncology and infectious disease studies.

Research Area

Cell Biology, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 644-78-0
• MW: 224.255
• Purity: 99.60% (May vary between batches)
• Formula: C₁₅H₁₂O₂
• SMILES: O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2O
• Target: Bcl-2 Family,Parasite,NF-κB,Apoptosis
• Solubility: DMSO:22.5 mg/mL (100.33 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.92 mM)

Bioactivity

• In Vitro:
  2-hydroxychalcone induced apoptosis by Bcl-2 downregulation. 2-hydroxychalcone and xanthohumol exerted more potent inhibitory effects on the proliferation, MMP-9 expression and invasive phenotype of MDA-MB-231 than chalcone.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNBC, 2 Hydroxychalcone, 2-(2-Hydroxybenzal)Acetophenone, 2Hydroxychalcone, 2-Hydroxychalcone, Bcl-2 Family, Apoptosis, Inhibitor, inhibit, NFkB, NF-kB, NF-κB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB

Compound Identifiers

PubChem CID

5367146